Search PubMed for publications by Dr Mitzi Nagarkatti
Select Publications out of a total of ~110:
1. McKallip, R.J., Nagarkatti, P.S. and Nagarkatti, M.
Delta-9-tetrahydrocannabinol exposure leads to increased breast cancer growth
and metastasis mediated by suppression of the anti-tumor immune response. J.
Immunol. 174:3281-9, 2005
2. Camacho, I.A., Hegde, V.L., Nagarkatti, M., and Nagarkatti, P.S. Treatment of
mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to AhR-dependent nuclear
translocation of NF-B and expression of FasL in thymic stromal cells and
consequent apoptosis in T cells. J. Immunol. 175:90-103, 2005.
3. Brown, N., Nagarkatti, M. and Nagarkatti, P.S. Diethylstilbestrol alters
positive and negative selection of T cells in the thymus and modulates T-cell
repertoire in the periphery.
Toxicol Appl Pharmacol. 2005 Aug 23 [Epub ahead of print]
4. McKallip, R. J., Nagarkatti, M. and Nagarkatti, P.S.
Delta-9-tetrahydorcannabinol enhances breast cancer growth and metastasis by
suppression of the antitumor immune response. J. Immunol. 174:3281-3289, 2005.
5. McKallip,R.J., Szakal, A.K., Nagarkatti, P.S. and Nagarkatti, M. The role of
CD44 in SEB-induced hepatitis: CD44 deficiency leads to reduced lymphocyte
apoptosis resulting in increased liver damage. Infection and Immunity 73:50-61,
2005.
6. Fisher, M.T., Nagarkatti, M., and Nagarkatti, P. S.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhances negative selection of T
cells in the thymus while allowing auto-reactive T cells to escape deletion and
migrate to the periphery. Mol. Pharmacol. 67:327-35, 2005.
7. Do, Y., Hegde, V.L., Nagarkatti, P. S. and Nagarkatti, M. Bryostatin-1
enhances the maturation and antigen-presenting ability of murine and human
dendritic cells. Cancer Research 64:6756-6765, 2004.
8. Do,Y., McKallip, R.J., Nagarkatti, M. and Nagarkatti, P.S. Activation through
cannabinoid receptors 1 and 2 on dendritic cells triggers nuclear factor-kB-dependent
apoptosis: Novel role for endogenous and exogenous cannabinoids in
immunoregulation. J. Immunol. 173:2373-2382, 2004.
9. Fisher, M.T., Nagarkatti, M. and Nagarkatti, P. S. Combined screening of
thymocytes using apoptosis-specific cDNA array and promoter analysis yields
novel gene targets mediating TCDD-induced toxicity. Toxicol. Sci. 78:116-124,
2004.
10. Do, Y., Nagarkatti, P.S. and Nagarkatti, M. Role of CD44 and hyaluronic acid
(HA) in activation of alloreactive and antigen-specific T cells by bone
marrow-derived dendritic cells. J Immunother. 27:1-12, 2004.
11. McKallip, R.J., Fisher, M., Szakal, A.K., Gunthert, U., Nagarkatti, P. S.
and Nagarkatti, M. Targeted deletion of CD44v7 exon leads to decreased
endothelial cell injury and vascular leak syndrome induced by IL-2 activated
cytolytic lymphocytes. J. Biol. Chem 278:43818-30, 2003.
12. Do, Y., Mckallip, R., Nagarkatti, P. and Nagarkatti, M. Combined deficiency
of CD44 and Fas leads to early onset and more severe form of lymphoproliferative
disease in the murine host. Int. Immunol. 15:1327-40, 2003.
13. Mckallip, R., Do,Y., Nagarkatti, P. and Nagarkatti, M. Role of CD44 in
activation-induced cell death: CD44 deficient mice exhibit enhanced T cell
response to conventional and superantigens. Int. Immunol. 14:1015-1026, 2002
14. Mustafa, A., McKallip, R.J., Fisher, M., Duncan, R., Nagarkatti, P.S.,
Nagarkatti, M. Regulation of IL-2-induced vascular leak syndrome by targeting
CD44 using HA and anti-CD44 antibodies. J. Immunotherapy 25:476-488, 2002
15. McKallip, R.J., Lombard, C., Fisher, M., Martin, B.R., Nagarkatti, M. and
Nagarkatti, P.S.. Delta-9-tetrahydrocannabinol-induced apoptosis in the thymus
and spleen as a mechanism of immunosuppression in vivo. J. Pharmacol. Exp.
Therap. 302:451-465, 2002
16. McKallip, R.J., Lombard, C., Fisher, M., Martin, B.R., Ryu, S., Nagarkatti,
P.S. and Nagarkatti, M. Targeting CB2 cannabinoid receptors as a novel therapy
to treat malignancies of the immune system. Blood 100:627-634, 2002.
17. Do, Y., Ryu, S., Nagarkatti, M. and Nagarkatti, P. S. Role of death receptor
pathway in estradiol-induced T-cell apoptosis in vivo Toxicol. Sci. 70:63-72,
2002
18. Chen, D., McKallip, R.J., Zeytun, A., Do, Y., Lombard, C., Robertson, J.L.,
Mak, T.W., Nagarkatti, P.S. and Nagarkatti, M. CD44-deficient mice exhibit
enhanced hepatitis after concanavalin A injection: evidence for involvement of
CD44 in activation-induced cell death. J. Immunol 166:5889-5897, 2001
19. Zeytun, A., Nagarkatti, M. and Nagarkatti, P. S. Growth of FasL-bearing
tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas+
organs. Blood 95:2111-2117, 2000
20. Rafi-Janajreh, A., Chen, D., Schmits, R., Mak, T. W., Grayson, R. L.,
Sponenberg, D. P., Nagarkatti, M. and Nagarkatti, P. S. Evidence For the
Involvement of CD44 in Endothelial Cell Injury and Induction of Vascular Leak
Syndrome by Interleukin-2. J. Immunol. 163:1619-1627, 1999.
21. Kamath, A. B., Camacho, I., Nagarkatti, P. S. and Nagarkatti, M. Role of
Fas-Fas ligand interactions in 2, 3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced
immunotoxicity. Toxicol. Appl. Pharmacol. 160:141-155, 1999.
22. Bradley, M. J., Zeytun, A., Rafi-Janajreh, A., Nagarkatti, P.S. and
Nagarkatti, M. Role of spontaneous and IL-2 induced NK activity in the
cytotoxicity and rejection of Fas+ and Fas- tumor cells. Blood 92:4248-4255,
1998.
23. Rafi, A. Q., Zeytun, A., Bradley M. J., Sponenberg, D.P., Grayson, R. L.,
Nagarkatti, M. and Nagarkatti, P. S. Evidence for the involvement of Fas ligand
and perforin in the induction of vascular leak syndrome. J. Immunol.
161:3077-3086, 1998.
24. Kamath, A. B., Nagarkatti, P. S. and Nagarkatti, M. Characterization of
phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on
thymocytes in vivo and its effect on apoptosis. Toxicol. Appl. Pharmacol. 149:
117-124, 1998.
25. Zeytun, A., Hassuneh, M., Nagarkatti, M. and Nagarkatti, P. S. Fas-Fas
ligand based interactions between tumor cells and tumor-specific CTL: A lethal
two-way street. Blood 90:1952-1959, 1997.
26. Kamath, A. B., Xu, H., Nagarkatti, P. S. and Nagarkatti, M. Evidence for the
induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in
vivo. Toxicol. Appl. Pharmacol. 142:367-377, 1997.
27. Rafi, A., Nagarkatti, M. and Nagarkatti, P. S. Hyaluronate-CD44 interactions
can induce murine B cell activation. Blood 89:2901-2908, 1997.
28. Hassuneh, M. R., Nagarkatti, P. S. and Nagarkatti, M. Evidence for the
participation of IL-2 and IL-4 in the regulation of autonomous growth and
tumorigenesis of transformed cells of lymphoid origin. Blood 89:610-620, 1997.
29. Hammond McKibben D., Seth, A., Nagarkatti, P. S. and Nagarkatti, M.
Characterization of factors regulating successful immunotherapy using tumor
specific cytotoxic T lymphocyte clone: Role of interleukin 2, cycling pattern of
lytic activity and adhesion molecules. Int. J. Cancer 60:828-836, 1995.
30. McKallip, R., Nagarkatti, M. and Nagarkatti, P. S. Immunotoxicity of AZT:
Inhibitory effect on thymocyte differentiation and peripheral T cell
responsiveness to gp120 of HIV. Tox. Appl. Pharmacol.131: 53-62, 1995.
31. Nagarkatti, M., Hassuneh, M., Seth, A., Manickasundari, K. and Nagarkatti,
P. S. Constitutive activation of IL 2 gene in the induction of spontaneous in
vitro transformation and tumorigenicity of a T cell line. Proc. Natl. Acad. Sci.
USA 91:7638-7642, 1994.
32. Hammond, D., Nagarkatti, P. S., Gote, L., Seth, A., Hassuneh, M. and
Nagarkatti, M. Double negative T cells from MRL lpr/lpr mice mediate cytolytic
activity when triggered through adhesion molecules and constitutively express
perforin gene. J. Exp.Med. 178:2225 2230, 1993.
33. Seth, A., Gote, L., Nagarkatti, M. and Nagarkatti, P. S. T cell receptor
independent activation of cytolytic activity of cytotoxic T lymphocytes mediated
through CD44 and gp90MEL-14. Proc. Natl. Acad. Sci. USA 88:7877 7881, 1991.
34. Dean, T., Kakkanaiah, V.N., Nagarkatti, M. and Nagarkatti, P.S.
Immunosuppression by aldicarb of T cell responses to antigen specific and
polyclonal stimuli results from defective IL 1 production by macrophages.
Toxicol. Appl. Pharmacol. 106:408 417, 1990.
35. Nagarkatti, M., Clary, S.R. and Nagarkatti, P. S. Characterization of tumor
infiltrating CD4+ T cells as Th1 cells based on lymphokine secretion and
functional properties. J. Immunol. 144:4898 4905, 1990.
36. Selvan, R. S., Nagarkatti, P. S. and Nagarkatti, M. Role of IL 2, IL 4 and
IL 6 in the growth and differentiation of tumor specific CD4+ T helper and CD8+
T cytotoxic cells. Int. J. Cancer 45:1096 1104, 1990.
37. Nagarkatti, M. Toney D. and Nagarkatti, P. S. Immunomodulation by various
nitrosoureas and its effect on the survival of the host bearing a syngeneic
tumor. Cancer Research 49:6587 6592, 1989.
38. Seth, A. Pyle, R. H., Nagarkatti, M. and Nagarkatti, P. S. Expression of the
J11d marker on L3T4+Lyt2- peripheral T lymphocytes of MRL lpr/lpr mice. J.
Immunol. 141:1120 1126, 1988.
39. Nagarkatti, M. and Kaplan, A.M. The role of suppressor T cells in BCNU
mediated rejection of a syngeneic tumor. J. Immunol. 135:1510 1516, 1985.
40. Nagarkatti, P. S., Nagarkatti, M. and Kaplan, A. M. Normal Lyt 1+2- T cells
have the unique capacity to respond to syngeneic autoreactivity T cells:
Demonstration of a T cell network. J. Exp. Medicine. 162:375, 1985.
41. Nagarkatti, P. S. and Nagarkatti, M. Effect of experimental dengue virus
infection on immune response of the host. I. Nature of changes in T suppressor
cell activity regulating the B and T cell responses to heterologous antigens. J.
Gen. Virology 64:1441, 1983. |
