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Office: 803 253 5838
Fax: 803 733 1515
E-mail: npsingh
@gw.med.sc.edu
Department of Pathology, Microbiology
and Immunology,
University
of South Carolina School of Medicine, Columbia, SC 29208 |
Recent Publications
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Publications
1 Singh, N.P., Venkatesh L. Hegde, Lorne J. Hofseth, Mitzi Nagarkatti, and
Prakash S. Nagarkatti. 2007. Resveratrol (trans-3,5,4'-trihydroxystilbene)
ameliorates Experimental Allergic Encephalomyelitis (EAE) primarily via
induction of apoptosis in T cells involving activation of AhR and ER. Molecular
Pharmacology. 72(6). (Fast Forward 13 September 2007).
2 Eplek, K.G., Chantale Lacelle, N. P. Singh, Esma S. Yolcu, and Haval Shirwan.
2007. CD4+CD25+ T Regulatory Cells Dominate Multiple Immune Evasion Mechanisms
in Early but Not Late Phases of Tumor Development in a B Cell Lymphoma Model.
Journal of Immunology. 178(11):6840-6848.
3 Singh, N.P., Mitzi Nagarkatti, and Prakash S. Nagarkatti. 2007. Role of dioxin
response element (DRE) and NF-kappaB (NF-kB) motifs in TCDD
(2,3,7,8-Tetrachlorodibenzo-p-Dioxin)-mediated regulation of Fas and Fas Ligand
expression. Molecular Pharmacology. 71.145-157.
4 Wentao Jia, Venkatesh L. Hegde, N. P. Singh, Daniel Sisco, Steven Grant, Mitzi
Nagarkatti, and Prakash S. Nagarkatti. 2006. Delta
9-tetrahydrocannabinol-induced apoptosis in leukemic cells is regulated by
translocation of Bad to mitochondria through disruption of RAF/MEK/ERK/RSK
pathway. Molecular Cancer Research. 4(8):549-562.
5 Singh, N.P., R.W. Miller, E. Yolcu, M.O. Kilinc, M. Oechsli, R.Huseby, D.D.
Taylor, M.T. Perry, R.V. LaRocca, and Haval Shirwan. 2006. Primary tumor cells
from cancer patients decorated with a novel form of CD80 protein serve as
effective antigen-presenting cells for the induction of autologous T-cell immune
responses ex vivo. Human Gene Therapy. 17:334-346.
6 Kilinc, M.O., L. Mukundan, E.S. Yolcu, N.P. Singh, J. Suttles, and H. Shirwan.
2006. Generation of multimeric form of CD40L with potent immunomodulatory
activity using streptavidin as a chepron. Experimental and Molecular Pathology.
80:252-261.
7 Singh, N.P., E.S. Yolcu, N. Askenasy, Haval Shirwan. 2005. ProtExTM: A novel
technology to display exogenous proteins on the cell surface and its use in
immunomodulation for the treatment of cancer. Annals of New York Academy of
Sciences. 1056:344-358.
8 Camacho, I. A., N.P. Singh, Venkatesh L. Hegde, Mitzi Nagarkatt, and Prakash
S. Nagarkatti. 2005. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin
leads to AhR-dependent nuclear translocation of NF-κB and expression of FasL in
thymic stromal cells and consequent apoptosis in T cells. Journal of Immunology.
175(1): 90-103. Received “Best Paper of the Year Award” by Society of
Toxicology. 2007.
9 Singh, N. P., Luping Guo, Xingyi Que, and Haval Shirwan. 2004. Blockade of the
indirect recognition pathway mediated by CD4+ T cells leads to prolonged cardiac
xenograft survival. Xenotransplantation. 10, 33-42.
10 Singh, N. P., Esma S. Yolcu, Douglas D. Taylor, Cicek Gercel-Taylor, Daniel
S. Metzinger, Stephen K. Dreisbach and Haval Shirwan. 2003. A novel approach to
cancer immunotherapy: tumor cells decorated with CD80 generate effective
antitumor immunity. Cancer Research. 63,4067-4073.
11 Singh, N. P., Luping Guo, Anna Mhoyan, and Haval Shirwan. 2003. Predominant
expression of Th2 cytokines and IFN- in acutely rejected xenografts.
Transplantation. 75, 586-590.
12 Yolcu, E. S., N. Askenasy*. N.P. Singh.*Equal contribution, Lamhamedi
Cherradi, H. Shirwan. 2002. Modification of the cell membrane for rapid display
of exogenous proteins as a novel means of immunomodulation: FasL-decorated
splenocytes prevent islet allograft rejection. Immunity, 17: 795-808.
13 Singh, N. P. and Haval Shirwan. 2000. Immunobiology of xenotransplantation.
In S. G. Pandalai (ed.), Recent Research Developments in Immunology (Part-I). 2,
347-373.
14 Lawrence, C. B., N.P. Singh, J. Qiu, R. G. Gardner, and Sadik Tuzun. 2000.
Constitutive hydrolytic enzymes are associated with polygenic resistance of
tomato to Alterneria solani and may function as an elicitor release mechanism.
Physiological and Molecular Plant Pathology. 57, 211-220.
15 Singh, N. P. and Haval Shirwan. 2000. Indirect recognition and Th2 response
play critical roles in cardiac xenograft rejection. Transplantation. 69, No 8:
257.
16 Singh, N. P., X. Que, and H. Shirwan. 1999. Contribution of the Indirect
Recognition Pathway to Cardiac Graft Rejection in the Rat-to-Mouse Xenograft
Model. Transplantation. S 555.
17 Singh, N. P. and A. O. Zalensky. 1997. Changes in structural organization of
bacterial Sym-plasmid during Pisum sativum-Rhizobium leguminosarum bv viciae
symbiosis. The Nucleus. 40 (1,2): 13-21.
18 Singh, N. P., J. A. Brennan, D. Niemeyer, K. J. Shuler, G. H. Veltri, J. C.
Egan, and V. G. DelVecchio. 1997. Novel detection methods for rare malignant
cells and histologically benign surgical margins and lymph nodes.
Otolaryngology-Head and Neck Surgery. 117 (2): P30.
19 Shaw, J. J., J. Wu, N.P. Singh, W. Mahaffee, F. Dane, and A. E. Brown. 1996.
Bioluminescent, Antibiotic and Chromogenic markers for bacteria. In Linda S.
Thomashow (ed.), The Manual of Environment Microbiology, 1st ed. ASM Press,
Washington D. C., USA, PP 466-472.
20 Singh, N. P., M. Moore, D. Niemeyer, J. Brennan, and V. G. DelVecchio. 1996.
Detection of mutations in p53 gene by a rapid non-isotopic PCR-based method.
Clinical Chemistry. 42: 1894.
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