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The MBS Program Manual in full (2006 version)
Degree Requirements
1. Interim Advisor
The Director of the Biomedical Sciences Graduate
Program will serve as Interim Advisor to MBS students until they
have selected a major professor. The interim advisor will assist
the student in the selection of a beginning course of study and in
the selection of laboratory rotations and a thesis advisor where
applicable. The interim advisor will also ensure that all early
requirements are met. At all stages in the student’s participation
in the graduate program, the interim advisor will try to ensure the
smooth progress of the student through the program. A permanent
graduate faculty advisor should be appointed as soon as an area of
laboratory or library research is identified.
2. Transfer Credits and Course Substitution for
Advanced Standing
Courses cannot be transferred to the MBS program
3. Academic Regulations
a.
Grades and Academic Progress
Graduate courses may be passed for degree credit with
a grade as low as C, but the student’s average on all courses
attempted for graduate credit must be at least B (3.0 on a 4 point
system). Graduate students whose cumulative grade point average
drops below B (3.00) will be placed on academic probation and
allowed one calendar year in which to raise the grade point average
to at least 3.00. Students who do not reach a cumulative 3.00 grade
point average during the grace period will not be permitted to
enroll for further graduate course work in that degree program.
Appeals for reinstatement to degree candidacy may be made first to
the Biomedical Science Graduate Program and then forwarded to the
Dean of the Graduate School.
b.
Graduate Assistantships
MBS students are not provided stipend support in the
first year.
Moreover, it should be noted that tuition is charged by the Graduate
School. Since foreign students must have evidence of support
throughout their time in the United States, such students cannot be
admitted to the MBS program unless they are able to demonstrate
access to enough funds to maintain themselves throughout their
studies.
Once an advisor is chosen, mentors may elect to provide
stipend support in the second year to MBS students doing research in
their labs in which case the student may be considered to be a
Graduate Assistant. No such support is available for the other
options.
Whereas the Graduate Office coordinates administrative processing of
appointment forms at the start of each fiscal year, supervision of
graduate assistants is delegated to the major professor or to an
appointed advisor prior to selection of the major professor.
Graduate assistants are not normally expected to work during
examination periods and school holidays; students on 12 month
appointment may also take additional vacation at a time approved by
the supervisor. It is the responsibility of the supervisor to
discuss the period of appointment, work schedule, specific duties,
manner, method, and schedule of evaluation with the graduate
assistant. Regular reviews should give feedback to the graduate
assistant about areas of excellent performance and substandard
performance which are detailed enough to make clear what results are
desired.
c.
Pass-Fail Option
This option is available for courses whose content is related to the
Program of Study, but in an area requiring a different training or
background. The past-fail option permits enrichment of a student’s
experience without affecting the grade point average. Courses
required by the program may not be taken on a pass-fail basis.
4. YEAR ONE
a. Curriculum
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The annual Graduate Studies Bulletin
website
http://www.sc.edu/bulletin/grad/index.html lists,
with a brief description, all graduate course offered by
the University of South Carolina, arranged by graduate
program and department. The Master Schedule accessed
from the Registrar’s website
http://registrar.sc.edu/ lists which courses are
offered in a given semester, as well as meeting time,
place, and instructor.
In order to satisfy program requirements,
the sequences below are strongly recommended for all
first year students:
MOLECULAR AND CELLULAR BIOLOGY TRACK
First semester
BIOL 711 - Structure-Function Nucleic
Acids - 3 credit hours
BIOL 717 - Biological Chemistry - 3
credit hours
BMSC 700 - Interdisciplinary Lab I - 1
credit hour
BMSC 702 - Medical Cell Biology - 4
credit hours
BMSC 801 - Seminar in Biomedical Sciences
- 2 credit hours
Second semester
BIOL 718 - Intermediary Metabolism - 3
credit hours
BMSC 801 - Seminar in Biomedical Sciences
- 2 credit hours
ANAT, MBIM, PATH, or PHPH 780 –Research
(laboratory rotation(s)) – 1 or more credit hours
Other items, such as journal clubs, may
be recommended. The Biomedical Sciences Graduate
Committee may recommend additional course work in
special circumstances.
NEUROSCIENCE TRACK
First
semester
First
semester students are required to complete at least 6
Neuroscience Basic Modules (PHPH752; or Fundamental
Psychology Modules).
Neurobiology Basics training modules (A,B,C,D,E,F,G, H,
I) will provide students with neuroscience-based
literacy using a modular format that can accommodate
training graduate students from diverse backgrounds
ranging from psychology to cell & molecular biology.
Each 5- week module (2 hrs, 30 min twice a week)
provides basic literacy in neuroanatomy,
neurophysiology, neurochemistry, neuropharmacology, or
molecular neuroscience, plus the needed proficiency in
physiology and quantitative methods required for
conducting research in neurobiology.
Students
may substitute other electives (Protein and/or Nucleic
acid biochemistry) for these modules, or may take
additional modules in their second year of training.
Additional Fundamental Psychology Modules may be used to
fulfill this requirement as well: Cognitive Psychology,
Developmental Psychology, Learning and Motivation,
Cognitive Neuroscience, Cognitive Developmental
Neuroscience, Integration across areas of Psychology.
PHPH752A: Neuroanatomy
PHPH752B: Neurochemistry-Fundamental concepts
PHPH752C: Neurochemistry-Advanced concepts
PHPH752D: Neurophysiology
PHPH752E: Physiology for neurobiologists
PHPH752F: Neuropharmacology
PHPH752G: Molecular Neurobiology
PHPH752H: Quantitative methods in Neurobiology
PHPH752I: Special Topics
Second
semester
Students will be required to take three of the
Neurobiology of Disease Modules (PHPH753).
PHPH753A: Stress, Anxiety Disorders and the
Amygdala
PHPH753B: Stress, Depression and the Hippocampus
PHPH753C: Degenerative diseases of old age
PHPH753D: Chronic Pain & Analgesia
PHPH753E: Schizophrenia, Prefrontal Cortex &
Executive Function
PHPH753F: Epilepsy
Other
elective courses:
BMSC 702
& 705 Medical Cell Biology I & II;
CHEM
751, 752 & 753 Biochemistry;
PHPH 701
Physiology for the Health Sciences;
PHPH 750
& 751 Fundamental Neuroscience I & II;
PSYC 709
& 710 Basic Quantitative Methods
Other items, such as journal clubs, may
be recommended. The Biomedical Sciences Graduate
Committee may recommend additional course work in
special circumstances.
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b. Discussing the Research Interests of
the Faculty
In the first semester, students are expected to meet the faculty to
familiarize themselves with the ongoing research in the Biomedical
Science Graduate Program. To help the student, symposia with
potential mentors will be scheduled at the beginning of the first
semester. Students are also encouraged to meet with potential
mentors individually.
c. Laboratory Rotations (students in the
laboratory research track)
A
laboratory rotation will usually consist of 2-8 weeks of research
experience working with a faculty member; this may consist of a
small independent project or of a component of an on-going project.
A student who undertakes a laboratory rotation with a faculty member
is under no obligation whatsoever to continue thesis research with
that professor. A student will usually start rotations in his/her
first semester.
To ensure the smooth progression of the student through the program,
it is a program requirement that students must do one or more
for-credit rotations in the spring semester of the first year. To
identify the mentor for this required rotation so that a
corresponding section of a research course can be set for
registration, students must complete Form 1 (see Appendix) and
return to the Graduate Office prior to registration for the spring
semester. MBS students in the laboratory research option should have
designated a mentor by the end of the second semester of their first
year.
d. Students in the non-laboratory
research option
Students who wish to write a thesis using library research must also
select a major professor who will advise on the topic of research.
The topic will be decided jointly by the student and the professor.
The student and the professor will hold monthly meetings to assess
the progress of the research. It is expected that the thesis will
consist of a major review of the literature of a topic of interest
to both the student and the professor. It is expected that the
thesis project will be pursued concurrently with courses in year 1
and as a major project in year 2.
e. Students in the biotechnology option
Students in the biotechnology option will pursue courses in the
molecular and cellular biology or the neuroscience track according
to their interests during the first year. These students do not
select a major professor. In year one, their advisor is the Director
of the Biomedical Sciences Graduate Program. In the summer of years
one and two, the student will complete a thesis under the direction
of the Director of the USC School of Medicine Instrumentation
Resource Facility (Dr Robert Price) and the Director of the
Biomedical Sciences Graduate Program (Dr Richard Hunt). This thesis
is not expected to be as extensive as that in the library research
option.
f. Selection of Major Professor
The selection of major professor by students in the laboratory or
library research options is by mutual agreement and is formalized by
submission to the Office of Graduate Studies of a completed
“Selection of Major Professor” form (Form 2, see Appendix).
It is important that the selection of a major professor be an
informed decision by student and advisor. The symposia in the first
semester by potential advisors to showcase their research interests
will give students the opportunity to select faculty with whom they
share an interest. Rotations, in the case of laboratory research
students, allow the student and faculty to determine on a trial
basis whether they can act productively in a student/mentor
relationship and whether the student can commit to a specific area
of research.
The choice of a major professor by a graduate student and the
acceptance of the role of major professor by a faculty member, are
important decisions which imply a certain sense of obligation on
both sides. The choice of a major professor is normally made with
every intention of that being a final decision. However, it is
appreciated that a student may decide that the choice was
inappropriate for that student; therefore a mechanism exists for
changing the major professor. It is pointed out to the student that
this is not a decision to be taken lightly. It will almost
certainly delay completion of his/her degree program as it will be
necessary to develop a new thesis research program and have it
approved.
In the event that a graduate student deems a change of major
professor necessary, the following procedures will apply:
1) The student and the advisor should attempt to reconcile their
misunderstandings and differences, or, if they mutually agree that a
change is advisable, they should arrange for a mutually satisfactory
transition.
2) If initial attempts at reconciling differences are
unsuccessful, the student and faculty member should confer with the
student’s Advisory Committee and attempt to reconcile their
differences.
3) In the event that no solutions emerge from these deliberations,
the Director of the Biomedical Sciences Graduate Program will serve
as an intermediary to arrange for a mutually satisfactory
transition.
g.
Qualifying and Comprehensive Examinations
There is no qualifying or comprehensive exam in the MBS program
h. Advisory Committee
At the end of the first year, the advisor and the student should
provide Ms Roberts in the Office of Graduate Studies with a list of
suggested committee members with appropriate expertise for their
research area. Including the mentor, the advisory committee must
consist of at least three members of the USC graduate faculty
(readers), with at least one outside the student’s research area but
within the Biomedical Science Graduate Program.
The Advisory Committee shall be responsible for approval of the
student’s program of study and the approval of a thesis research
project and thesis. The Advisory Committee should discourage
research by students on projects with no assurances of the free
exchange of ideas and scientific information. In addition, the
Advisory Committee is responsible for monitoring the student’s
research progress through conferences (approximately three times a
year). The Committee Chair will be responsible for notifying the
Director of the Biomedical Sciences Graduate Program, in writing
(with a copy to the Office of Graduate Studies), of all official
actions of the Committee.
It is anticipated that the composition of the Advisory Committee
will change only if there is a change in direction of research by
the student, in which case an additional member with expertise in
that area may be requested to join the committee, and a member who
was appointed because of an area of expertise which is no longer
relevant may volunteer to resign. If a student changes his major
advisor, a new Advisory Committee will be appointed.
g. Program of Study
Every student must submit a Program of Study to the Graduate School
that specifies all required courses. In addition to the first year
core curricula, MBS students are required to take a minimum of one
elective course of at least three credit hours each at the 700 or
800 level that is approved by the student’s advisory committee. This
form with current Biomedical Science requirements may be accessed in
Microsoft Word format from the Biomedical Science program
requirements and curriculum website for enrolled students. The
program is determined with the research mentor and advisory
committee and should be submitted by the end of the first year.
The program of study must total at least 32 graduate credits
with at least 1 credit of BMSC 799 Thesis Preparation. As many as 12
graduate credits may be taken in USC schools and colleges other than
the School of Medicine. This option provides great flexibility to
tailor programs individually and draw on the wider resources of a
comprehensive university. At least 50% of graduate credits,
exclusive of thesis, must be at the 700 level. Up to 6 credits may
be taken as thesis preparation and up to 6 credits may be taken as
research or independent study.
5. YEAR TWO
a.
Curriculum
Generally, students will complete the remainder of their courses in year
two. In addition to the above requirements, the student is expected to
attend the weekly Biomedical Sciences Seminar Series each semester and
register for BMSC 801. Other items, such as journal clubs may be
recommended. The Advisory Committee may recommend additional course
work in special circumstances.
By
the end of the first year, in the case of the laboratory or library
research options, the student should have formulated specific goals for
the thesis research proposal. A written proposal should be submitted to
and approved by the Advisory Committee by the end of year one. The
proposal should include:
1)
a review of the relevant literature
2)
an outline of the nature of the problem that the student wishes to
investigate for his dissertation research
3)
an outline of the proposed experimental approach(es) to be used in the
dissertation research
In
the case of the library research option, the proposal will be based in
items 1 and 2 above.
For
students following the biotechnology track, year two will consist of the
following curriculum:
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FALL
SEMESTER
IMAGING
Light
Microscopy (4 weeks)
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Theory
and Instrumentation
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Specimen
Processing for Paraffin and Cryo-sectioning
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Routine
stains – Hematoxylin and Eosin
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Special
stains – PAS, Trichromes etc
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Immunohistochemistry including antigen retrieval methods
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In situ
hybridization – slides and whole mounts
Digital
Imaging (2 weeks)
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Description of digital images
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Image
enhancement
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Image
processing
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Ethics
in digital imaging
Confocal
Microscopy (3 weeks)
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Theory
and Instrumentation
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Specimen
Processing
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2D Image
Collection and Analysis
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3D Image
Collection and Reconstruction
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Advanced
techniques – i.e. FRET, FRAP
Live Cell
Imaging (2 weeks)
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Cell
Culture Techniques
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Theory
and Instrumentation
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Short
term imaging – i.e. pH and calcium flux imaging
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Long
term imaging – i.e. cell division and migration assays
Scanning
and Transmission Electron Microscopy (4 weeks)
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Theory
and Instrumentation
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Specimen
Processing
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Operation of Scanning EM
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Operation of Transmission EM
Small
Animal Ultrasound Imaging (1 week)
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Theory
and Instrumentation
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Cardiovascular Imaging
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Abdominal and Cancer Imaging
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SPRING SEMESTER
GENOMICS AND PROTEOMICS
Laser
Capture Micro-dissection and Agilent 2100 Bioanalyzer (2 weeks)
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Theory
and Instrumentation
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Specimen
prep and quality control for DNA, RNA and Protein
Applications
DNA
Microarrays (3 weeks)
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Theory
and Instrumentation
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Specimen
Preparation
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Spotting
and Data Collection
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Data
Analysis
Real Time
PCR (2 weeks)
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Theory
and Instrumentation
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Specimen
Preparation
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Data
collection and analysis
Mass
Spectrometry (2 weeks)
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Theory
and Instrumentation
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Specimen
Preparation
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Data
collection and analysis
Western
and Northern blotting (3 weeks)
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Theory
and Instrumentation (BioRad FX, Kodak IM 2000 systems)
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Specimen
Preparation
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Data
collection and analysis
Flow
Based Techniques (4 weeks)
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Theory
and Instrumentation (Bioplex, FACS, Sterile Cell Sorting)
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Specimen
Preparation
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Data
collection and analysis
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b.
Thesis Defense
The
student’s written thesis, which is the culmination of graduate study,
should make a significant contribution to the body of current knowledge
in Biomedical Science. The student will be required, as the final act
before graduation, to present to the Advisory Committee an oral defense
of the thesis.
The
candidate may give a seminar as the first part of the thesis defense.
Scheduling and announcement of the seminar to the Biomedical Science
Program should be coordinated through the Graduate Office. The seminar
will be open to faculty and students, and questions will be invited from
the audience. Following the seminar, the candidate and his/her
committee will meet for additional questions; then the committee will
determine if the performance is satisfactory. Each member of the
committee signs (with black ink) the title page before it is taken to
the Graduate School for the Dean’s signature.
An
information packet “Thesis Guidelines” is available on the Graduate
School website. Instructions on thesis format, page numbering and
margins, paper quality, deadlines and the procedures for submitting the
official thesis and required copies to the Graduate School are included
in this packet. The deadline for submitting the signed thesis is
usually 15 or 20 days before commencement. The date, subject to change
by the Graduate School, is published in the master schedule each
semester. It is the responsibility of the graduating student to conform
to the deadline date and schedule the defense and exit appointments
accordingly. Note: when the student has
successfully defended his/her thesis, the Chair of the student’s
Advisory Committee should write a letter to the Director of the
Biomedical Sciences Graduate Program. A suggested format is shown in
the Appendix, Form 3.
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