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MEDICAL SCHOOL

UNIVERSITY OF SOUTH CAROLINA

The Cell and Developmental Biology and Anatomy department has a substantial research enterprise and numerous grants from both federal agencies such National Institutes of Health and private organizations such as the American Heart Association. There are two focus areas within the department: The Reproductive Biology group and  the Cardiovascular Development group. Among the interests of the Cardiovascular Development faculty are: The role of the extracellular matrix in the heart during normal growth and development and in certain disease conditions, the organization of various cell types in the developing heart, integrins in the transition from cardiac hypertrophy, the regulation of the LEK1 Protein in cardiomyocyte mitotic activity. The Reproductive Biology group studies mechanisms of multi-hormonal control of critical genes involved in ovarian cell differentiation and progesterone biosynthesis, adhesion molecules in spermatogenesis, environmental factors in mammalian spermatogenesis. 

The Faculty of the Pathology and Microbiology Department study many aspects of bacteriology, immunology and cell biology and have grants from the National Institutes of Health, the Department of Defense and various non-governmental sources. Among our interests are molecular markers that identify bacterial types such as anthrax, the immunology of the eye with particular reference to the function of dendritic cells in the retina, proliferative disease of the retina and the functions of retinal pigment epithelial cells, protection of the retina against oxidative damage, glaucoma and the trabecular meshwork of the eye, vaccine development, cell transformation by papilloma viruses, mechanisms of gene splicing

The Faculty of Pharmacology, Physiology and Neuroscience study: central nervous system adaptation to injury and disease,  forebrain dopamine and acetylcholine pathways, GABA receptors,  molecular mechanisms of steroid hormone action,  neurons in the amygdala,  changes that are produced by stress in the hippocampus,  cardiac ion channel proteins, neural control of cardiovascular function, gender-related influences on anxiety-related and seizure-related disorders, viral vectors for gene delivery and expression in neurons, the relationship between aging, estrogen and the brain