|
|
Office: 803 733 3399
Fax: 803 733 3192
E-mail:
patton
@med.sc.edu
Department of Pathology and
Microbiology, University of South Carolina School of Medicine, Columbia, SC
29208
|
|
After transcription, all RNAs, whether they are
transfer tRNAs (tRNAs), messenger RNAs (mRNAs), ribosomal RNAs (rRNAs) or
small nuclear RNAs (snRNAs), are put through a series of processing steps.
We are interested in discovering new protein factors that are involved in
the metabolism of small stable RNAs such as tRNAs and snRNAs. These RNAs are
instrumental in essential cellular processes such as protein synthesis and
mRNA splicing. We are particularly interested in understanding the formation
and function of nucleotide modifications in these RNAs, with an emphasis on
the formation of pseudouridine, an isomer of uridine. We have begun to use
Caenorhabditis elegans as a model system to define the roles of splicing and
modification factors prior to investigating the role of their homologues in
mammals.
|
|
|
Learn about the research of other faculty
|
|
