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PART THREE: VIROLOGY Virology is the study of viruses, complexes of nucleic acids and proteins that have the capacity for replication in animal, plant and bacterial cells. To replicate themselves, viruses usurp functions of the host cells on which they are parasites. The viral parasite causes changes in the cell, particularly its antigenicity; moreover, directing the host cell's metabolism to the production of new virus particles may cause cellular death. Virally-induced cell death, changes in antigenicity and the response of the host to the presence of the virus leads to the manifestations of viral disease. Viruses come in two basic types, those that have a genome of DNA and those that have a genome of RNA. THE CHAPTER NUMBERS AT THE LEFT ARE LINKED TO ILLUSTRATED HTML PAGES. THE LOGOS AT THE RIGHT TAKE YOU TO POWERPOINT SLIDE FILES AND ACROBAT LECTURES NOTES THAT ACCOMPANY THE WEB PAGES. THE POWERPOINT FILES MAY BE VERY LARGE AND THEREFORE DIFFICULT TO DOWNLOAD BY OUTSIDE USERSALL OF THE HTML PAGES INDICATED BY CHAPTER NUMBERS ARE NOW FREE OF PASSWORD PROTECTION - JUST CLICK ON THE ORANGE CHAPTER NUMBER ALL OF THE CHAPTERS
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| VIRUS GLOSSARY | ||||
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Images ©
Dr Linda
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CHAPTER ONE Definitions, Classification, Morphology and Chemistry |
An introduction to viruses, their nature, structure and classification |
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CHAPTER
TWO Virus replication Strategies |
Principal events involved in replication: Adsorption, penetration, uncoating nucleic acid and protein synthesis, assembly, maturation and release |
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CHAPTER THREE DNA Virus Replication Strategies |
Replicative strategies employed by animal DNA viruses. Identification of virus prototypes associated with different DNA virus replication schemes |
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CHAPTER FOUR RNA Virus Replication Strategies |
Replicative strategies employed by animal RNA viruses. Identification of virus prototypes associated with different RNA virus replication schemes |
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CHAPTER FIVE Viral Genetics |
Introduction to animal virus genetics
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CHAPTER SIX Oncogenic Viruses |
Viruses that cause cancer and the mechanisms by which they do so: DNA cancer viruses (polyoma, herpes, papilloma, hepatitis, adenovirus). RNA cancer viruses (retroviruses) |
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CHAPTER SEVEN Human Immunodeficiency Virus |
The
biology of the virus that causes AIDS
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CHAPTER EIGHT Molecular Approaches to the Development of Viral Vaccines |
History of vaccines especially smallpox and polio. New methods: subunit vaccines, anti-idiotype and DNA vaccines |
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CHAPTER NINE Viral Chemotherapy |
Drugs that have been used against viruses: Nucleoside analogs, reverse transcriptase inhibitors, protease inhibitors |
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CHAPTER TEN - PART ONE ENTEROVIRUSES CHAPTER TEN - PART TWO CHAPTER TEN - PART
THREE |
Picornaviruses: Small RNA viruses that cause infections of the alimentary tract including polio (enteroviruses) and of the upper respiratory tract (rhinoviruses) |
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CHAPTER ELEVEN Herpesvirus |
The structure of herpes viruses. The diseases caused by herpes simplex types 1 and 2, cytomegalovirus, varicella-zoster virus, Epstein-Barr virus and other herpes types. |
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CHAPTER TWELVE Virus-Host InteractionS |
Host specific and nonspecific defense mechanisms involved in resistance to and recovery from virus infections. Role of interferon in viral infections. Mechanisms by which interferon exerts its antiviral activity. Contributions of various host defense mechanisms in viral infections | |||
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CHAPTER THIRTEEN Influenza virus |
Influenza virus structure and properties. Viral pathogenesis and disease, genetics, epidemiology, prevention and treatment | |||
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CHAPTER
FOURTEEN Mumps, Measles |
Structure and properties of measles and mumps viruses.
Viral pathogenesis and disease, epidemiology, prevention and treatment |
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CHAPTER FIFTEEN Rubella |
Structure and properties of rubella virus. German Measles pathogenesis and disease, epidemiology, prevention and treatment | |||
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CHAPTER SIXTEEN Parainfluenza, Respiratory SyncYtial and Adeno Virus |
Viruses that cause respiratory disease |
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CHAPTER
SEVENTEEN Rotaviruses and Other Agents of Viral Gastroenteritis |
Viruses that cause alimentary tract infections |
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CHAPTER EIGHTEEN Hepatitis Viruses |
The structure and replication of hepatitis A to E |
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CHAPTER NINETEEN
- PART ONE HEPATITIS A AND E (Infectious and enteric non-A, non- B)
CHAPTER NINETEEN - PART TWO |
The diseases that are caused by the hepatitis viruses |
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CHAPTER TWENTY Rabies |
Rhabdoviruses and the disease of rabies |
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CHAPTER TWENTY
ONE Arboviruses
CHAPTER TWENTY TWO |
Arbovirus encephalitis, febrile and hemorrhagic disease. Rodent borne hemorrhagic fever, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Other filovirus-associated hemorrhagic fevers |
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CHAPTER TWENTY THREE Conventional and Unconventional Agents (Slow Viral Diseases) |
Slow viral diseases of the central nervous system. Progressive multifocal leukoencephalopathy. Sub-acute sclerosing panencephalitis (measles virus) Prion diseases: Kuru, Creutzfeld-Jakob disease |
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CHAPTER TWENTY FOUR Bacteriophage |
Structure of bacteriophage. The infectious process and the lytic multiplication cycle. The lysogenic cycle and its regulation. | |||
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CHAPTER
TWENTY FIVE CORONAVIRUSES - COLDS AND SARS |
The viruses that cause about one third of common colds and the newly described severe acute respiratory syndrome | |||
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CHAPTER TWENTY SIX PARVOVIRUSES AND FIFTH DISEASE |
Childhood rash disease | |||
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