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Office: 803 733 3281
Fax: 803 733 3192
E-mail:
mayer
@med.sc.edu
Department of Pathology, Microbiology
and Immunology, University of South Carolina School of Medicine, Columbia, SC
29208
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Resistance to infectious agents can often be enhanced by immunopotentiating
drugs. However, use of these drugs has been hampered because their effects
on the cellular components of the immune system are poorly understood. Dr.
Mayer is investigating the effects of natural and synthetic
immunopotentiating drugs on the numbers and functional capacities of
macrophages, lymphocytes, and their subpopulations by means of flow
cytometry. Information concerning the ability of an immunopotentiating drug
to enhance immune functions in a particular anatomical site is used to make
predictions concerning the effectiveness of the drug in enhancing resistance
to virus-induced pneumonia, hepatitis and encephalitis. These predictions
are then tested in animal models.
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